Introduction: Juvenile nasopharyngeal angiofibroma is a rare, highly .. Luiz A CR, Romualdo S LT, Fava A S. Angiofibroma nasofaríngeo: revisão de literatura. Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor arising predominantly in the nasopharynx of adolescent males. It is an aggressive. Juvenile nasopharyngeal angiofibromas (JNA) are a rare benign but locally aggressive vascular tumor. Epidemiology Juvenile nasopharyngeal angiofibromas.
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The other 17 patients underwent endoscopic surgery alone. These classification systems are based on examination methods, including Angiofibroja, MRI, and endoscopy, and have been utilized to establish the extent of the tumor, its pattern of spread, and consequently, surgical planning 10 11 12 16 17 18 National Center for Biotechnology InformationU.
Nasopharyngeal Angiofibroma: Review of the Genetic and Molecular Aspects
Steroid hormone receptor expression in nasopharyngeal angiofibromas. Home About Us Advertise Amazon.
In the 17 patients who underwent endoscopic approach alone, the mean operation time was min and the mean blood loss was mL; none required replacement of blood products. Current debate involves the hamartoma and vascular malformation theories. In spite of the existing controversy, the hormonal stimulation means remains a JNA therapeutic possible target. The terms chosen for the research were: Nasopharyngeal carcinoma Nasopharyngeal carcinoma. Like any other solid tumor, the Angiofibeoma depends on the growth of vessels that offer intake to its proliferation and growth, which justifies the search for proangiogenic growth factors in its pathogenesis.
Given the short period of patient follow-up, there were only two relapses in two years.
Non-surgical treatments are available, including the use of hormones estrogen, testosteroneradiation therapy, chemotherapy, and recently, embolization; however, surgery is considered the treatment of choice, with the route depending on the stage of naosfaringeo tumor and the overall condition of the patient 11,12, The JNA structure is duly characterized. However, as in any invasive procedure, nasofatingeo presents risks that should be fully explained to the patients Arch Otolaryngol Head Neck Surg.
The first description of an endoscopic resection was published in About Blog Go ad-free. JNA is an uncommon benign tumor predominantly affecting adolescent males. Growth factors and receptors in juvenile nasopharyngeal angiofibroma and nasal polyps: Endoscopic Surgery for Juvenile Angiofibroma: The tumor is limited to the sphenopalatine foramen, nasopharynx, and nasal cavity without bone destruction. The genomic imprinting is an alleles’ selective inactivation process that results in transcriptional silencing.
Many studies highlight the benefit of preoperative arterial embolization to control bleeding intraoperative 16 29 High levels of c-Kit CDa protein with tyrosine kinase nassofaringeo of the PDGFR platelets derivate growth factor receptors family, have already been related to other tumors. This feature may be helpful is differentiating from other nasoraringeo aggressive lesions.
Endoscopic Surgery for Juvenile Angiofibroma: JNA being an aggressive tumor may recur posttreatment. Several classification methods have been utilized to stage tumors and assist in choosing the appropriate treatment. All 20 patients were available for follow-up maximum, 7 yearswith none showing evidence of tumor recurrence. The excised gross specimen was soft to firm in consistency, white to yellow with darker vascular areas.
However the relevance of such statements is not known. A concise classification system and nasofarinbeo treatment options.
The nature of juvenile nasopharyngeal angiofibroma. Treatment for Nasopharyngeal angiofibroja JNA is primarily surgical. Articles from Journal of Oral and Maxillofacial Pathology: Histopathology reveals a fibrocellular stroma with spindle cells and haphazard arrangement of collagen interspersed with an irregular vascular pattern.
Retrieved 29 June These tests have led to the formulations of multiple classification methods, including the FischRadkowskiAndrewsBremerand Antonelli methods 1,4,5,7,8. All patients underwent angiography with embolization of the tumor days before surgery.
Pathology Outlines – Nasopharyngeal angiofibroma
Vascularization arises most frequently from the maxillary artery i. Most investigations about the JNA genetics leads to results unconcluded or that do not add too much information to the existing knowledge about the tumor. We analyzed findings in 20 patients who underwent surgery between and